Wednesday, May 22 2013 11:40 PM EDT2013-05-23 03:40:29 GMT
(WMC-TV) - The Memphis Police Department issued a city watch for a 12-year-old boy Wednesday night. Robert McBride II was last seen leaving his residence on foot on Jamaica Avenue. He has a mohawk, andMore >>
The Memphis Police Department canceled a city watch for a 12-year-old boy Wednesday night.More >>
Wednesday, May 22 2013 11:24 PM EDT2013-05-23 03:24:43 GMT
(WMC-TV) - A Memphis skateboard shop was going under until the Grizzlies' big wins, that is when owner Hunter Demster started selling T-shirts. The "Grind City" shirts saved his Midtown business whichMore >>
A Memphis skateboard shop was going under until the Grizzlies' big wins, that is when owner Hunter Demster started selling T-shirts.More >>
Wednesday, May 22 2013 11:11 PM EDT2013-05-23 03:11:49 GMT
(WMC-TV) - Cleanup has begun amid the rubble Oklahoma City Wednesday where an EF-5 tornado devastated the Moore community. More than 13,000 homes were damaged or destroyed, causing possibly $2 billionMore >>
Cleanup has begun amid the rubble Oklahoma City Wednesday where an EF-5 tornado devastated the Moore community.More >>
Wednesday, May 22 2013 11:00 PM EDT2013-05-23 03:00:22 GMT
(WMC-TV) - A Memphis mother defends her teenage son who is charged with murdering someone at a graduation party. Rebecca Miller and her son are anything but strangers to Action News 5. Our station helpedMore >>
A Memphis mother defends her teenage son who is charged with murdering someone at a graduation party.More >>
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SOURCE Cerecor Inc
BALTIMORE, March 20, 2013 /PRNewswire/ -- Cerecor Inc, a neuroscience biotech company that develops therapies that have the potential to make a difference in diseases with high unmet medical needs, today announced that it has acquired exclusive, worldwide rights to develop, register and commercialize agents that inhibit catechol-O-methyltransferase inhibitors ("COMT inhibitors"), previously discovered and owned by Merck, known as MSD outside the United States and Canada.
COMT is an enzyme that breaks down dopamine, a neurotransmitter that plays a key role in higher brain functions such as motivation, cognition and emotion. Drugs that inhibit COMT have been used to treat patients with Parkinson's disease; however, they have poor brain penetration and limited safety and tolerability. COMT inhibition also has broad potential applicability in other CNS diseases, such as addictive behaviors and schizophrenia, by specifically increasing dopamine levels in areas of the brain affected by these conditions. While the development of schizophrenia drugs to date has focused on reducing psychosis, improvement in functional outcome has been largely unattainable because current drugs do not have clinically significant impact on the "negative symptoms" and cognitive impairment of the disease. Drugs that inhibit COMT improve working memory and other measures of cognitive function in animals and in clinical studies (normal subjects and in schizophrenics).
"Merck has developed an innovative COMT platform that has addressed the toxicity associated with existing COMT drugs. By accessing this platform, Cerecor broadens its cognition pipeline, which also includes DAAO inhibitors. This enhances our leadership in neuropsychiatric drug development," stated Dr. Reza Mazhari, Cerecor's VP of Drug Discovery and Development.
Under the terms of the agreement, Cerecor will evaluate more than 2,000 molecules and select lead candidates for clinical development. Consideration includes milestone payments and royalties consistent with other preclinical licenses in neuroscience. Cerecor anticipates completing the technology transfer activities in 2013.
"Adding COMT inhibitors to our drug development portfolio enhances our mission. Cerecor continues to focus on targets or technologies that have demonstrated human proof of concept, and for which biomarkers could be used to steer early clinical development. We are delighted that Merck has chosen Cerecor to help realize the value of such an innovative body of work as contained within their COMT patent portfolio," added Dr. Blake Paterson, Cerecor's co-founder and CEO.
"Cerecor's approach to the development of safe and effective therapies, combined with its experienced management team, makes them ideally suited to help advance this platform targeted for the treatment of CNS diseases," said Dr. Richard Hargreaves, Vice President, Worldwide Head of Basic Research, Neuroscience, Merck Research Laboratories.
Cerecor Inc is a biopharmaceutical company focused on the discovery, development and commercialization of prescription pharmaceuticals whose primary activity is in the human nervous system. We are a Delaware corporation, based in Baltimore and co-founded in April 2011 by Drs. Solomon Snyder, Barbara Slusher, Blake Paterson and Mr. Isaac Blech. Cerecor is focused on translational medicine – the accelerated transfer of technology from the laboratory to early human trials, with the mission of commercializing therapeutics that make a difference.
Wednesday, May 22 2013 10:32 AM EDT2013-05-22 14:32:03 GMT
(WMC-TV) - It is a tiny pest with a big bite that can do major damage. One Germantown family said it only took one infected tick to change their entire lifestyle – something they have been dealing withMore >>
It is a tiny pest with a big bite that can do major damage.More >>
Wednesday, May 22 2013 4:46 PM EDT2013-05-22 20:46:13 GMT
(WMC-TV) - The man accused of killing a police officer walked out of jail a free man Wednesday afternoon. Action News 5's Nick Kenney was there as Timothy McKinney was released. McKinney was accused ofMore >>
The man who pleaded guilty to killing a police officer walked out of jail a free man Wednesday afternoon.More >>
Wednesday, May 22 2013 2:33 PM EDT2013-05-22 18:33:03 GMT
(WMC-TV) - The City of Memphis is saying "goodbye and good riddance" to blight. A derelict apartment complex, formerly called Park Place Apartments, sat vacant for four years breeding crime. It is nowMore >>
A derelict apartment complex, formerly called Park Place Apartments, sat vacant for four years breeding crime. It is now being demolished.More >>
Wednesday, May 22 2013 5:48 PM EDT2013-05-22 21:48:12 GMT
(WMC-TV) - More jobs are coming to Memphis and city leaders are rolling out the red carpet to celebrate. Kruger Products is a leading nationwide towel and tissue manufacturer. The company announced theyMore >>
A Canadian company announced that are adding hundreds of jobs to its North Memphis office. Kruger Products rolled out the red carpet Wednesday afternoon to celebrate the expansion.More >>
Wednesday, May 22 2013 12:48 PM EDT2013-05-22 16:48:44 GMT
(WMC-TV) - A Mid-South mom is convinced that one of her children was murdered. Frances Chambers has spent the past four years and a lot of money investigating the death of her son Demond. Police in herMore >>
A Mid-South mom is convinced that one of her children was murdered, despite the medical examiner's report. More >>
Wednesday, May 22 2013 6:10 PM EDT2013-05-22 22:10:09 GMT
(WMC-TV) - Wednesday is the very last day of school for students and also the last day of the Memphis City Schools system. Action News 5's Justin Hanson is speaking to longtime MCS teachers and volunteersMore >>
Wednesday is the very last day of school for students and also the last day of the Memphis City Schools system.More >>
Wednesday, May 22 2013 6:22 PM EDT2013-05-22 22:22:48 GMT
(WMC-TV) - The Memphis Police Department fired two of its officers Wednesday. Marc Henderson, 32, and Parker Culver, 29, were terminated for personal conduct and violate regulation. In February, thereMore >>
Marc Henderson, 32, and Parker Culver, 29, were terminated for personal conduct and aid to violate regulation.More >>
Wednesday, May 22 2013 6:21 PM EDT2013-05-22 22:21:12 GMT
(RNN) - British officials are saying one man is dead and two others were injured in a possible terrorist attack in London on Wednesday.According to BBC News, eyewitnesses said man was attacked in a streetMore >>
One man is dead after two men attacked him in broad daylight with knives and meat cleavers. More >>
Wednesday, May 22 2013 12:49 AM EDT2013-05-22 04:49:28 GMT
(WMC-TV) - A flood frustrated resident in a Southaven neighborhood called her backyard an ocean after severe weather Tuesday. Inside Louise Rinhart's home is not much better. "Carpet and I got hardwoodMore >>
A flood frustrated resident in a Southaven neighborhood called her backyard an ocean after severe weather Tuesday.More >>
Wednesday, May 22 2013 9:13 AM EDT2013-05-22 13:13:44 GMT
(WMC-TV) - Firefighters escorted several families from their flooded homes in Horn Lake after a rain-swollen creek rose beyond its banks Tuesday. The firefighters offered piggyback rides to children toMore >>
Firefighters escorted several families from their flooded homes in Horn Lake after a rain-swollen creek rose beyond its banks Tuesday.More >>